![]() ![]() The group requiring an elevated dose and those who were able to remain euthyroid on lower doses were similar in age, sex, weight, body mass index, and the prevalence of diabetes.Īll subjects took a serologic tissue transglutaminase test, and those with an elevated level underwent endoscopy with biopsies.Įight of the 400 patients had an elevated serum tissue transglutaminase level, and seven of the eight were subsequently confirmed as having biopsy-proven celiac disease. Zubarik and his coinvestigators selected those doses as their threshold in the cross-sectional study because their earlier retrospective study had suggested patients requiring that much levothyroxine might have an increased prevalence of concomitant celiac disease ( Am. Thirty percent of participants required 125 mcg or more of levothyroxine, and 29% needed at least 1.5 mcg/kg daily in order to maintain euthyroid status. Zubarik’s study averaged 59 years of age, and 82% were women. The 400 consecutive patients on treatment for hypothyroidism in Dr. A positive biopsy confirms the diagnosis and warrants initiation of a gluten-free diet. An elevated level triggers endoscopy with duodenal biopsies. Testing involves a simple serologic test for tissue transglutaminase. Zubarik, professor of medicine and director of GI endoscopy at the University of Vermont, Burlington. Thus, the 5% prevalence of celiac disease in hypothyroid patients requiring high-dose levothyroxine in order to maintain a euthyroid state is at least as high as, and perhaps higher than, the prevalence in groups having a guideline-recommended indication for testing, noted Dr. These include, for example, patients with asymptomatic iron-deficiency anemia, who have a celiac disease prevalence of 2.3%-5%. However, current national and international guidelines do recommend routine testing for case finding in selected populations known to be at increased risk of celiac disease. population isn’t recommended at present because the prevalence – 0.75% is deemed too low to justify such a practice. Mass screening for celiac disease in the broad U.S. In his cross-sectional study of 400 consecutive patients with hypothyroidism who underwent testing for celiac disease, 5% of those on a levothyroxine dose at or above that threshold were found to have biopsy-confirmed celiac disease. Zubarik asserted at the annual Digestive Disease Week. Please click here for detailed T&C.CHICAGO – Hypothyroid patients who need either at least 125 mcg or 1.5 mcg/kg of levothyroxine per day in order to remain euthyroid should routinely be tested for celiac disease, Dr. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. You should not use the information provided herein to diagnose, prevent, or cure a health problem. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. ![]()
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